Mangosteen and Arthritis – How does Mangosteen Help with Arthritis?

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Arthritis is a painful disease. The level of pain dependant on the type and the stage of arthritis you have.

Once you diagnosed as having arthritis, the next step is to find a right treatment for you. It can sometimes take time to find the treatment which works best for you since every individual has varying respond to different kind of treatment. The conventional way and the most effective way to relief arthritis pain is the drug. There are many types of drugs available to treat different types of arthritis.

Mangosteen and Arthritis – How do Conventional Drugs Help Relieve Pain in Arthritis?

NSAIDs – Nonsteriodal anti-inflammatory drugs are among the most common pain relief medicines in the world. How do those pills help so much in pain relief? Here is the explanation I got from webmd : NSAIDs help ease your pain and sometimes cause side effects in the process. To help you further understand what the drugs do to your body, let’s go back to basic question

What is Pain?

On a basic level, pain is the result of an electrical signal being sent from your nerves to your brain. Let say for example – you got a sprain. The damaged tissue releases chemicals called prostaglandins, which are like hormones. These prostaglandins not only cause the tissue to swell, they also amplify the electrical signal coming from the nerves. In another word, you feel an increased level of pain.

NSAIDs work on a chemical level. They block the effects of special enzymes - specifically COX-1 and COX-2 enzymes which are responsible in making prostaglandins. By blocking the COX enzymes, NSAIDs stop your body from making as many prostaglandins. For you, you feel less swelling and less pain.

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Mangosteen and Arthritis - What Are the Side Effects from Standard NSAIDs?

Most people who use NSAIDs for short term don't have any serious problems with them. However, for those who need pain relief regularly - there can be a downside. Here are the possible side effects:

  • Gastrointestinal Problems: There are many different types of prostaglandins in your body. One type of prostaglandin helps protect the lining of the stomach and it is produced by COX-1 enzyme. With regular intake of NSAIDs, it blocks COX-1 enzymes and affect the process of this prostaglandin. As a result, NSAIDs cause high rates of gastrointestinal problems such as indigestion and diarrhoea.
  • High Blood Pressure and Kidney Damage: NSAIDs reduce the blood flow to the kidneys and affect the functions of them. As a result, the fluid builds up in your body. The more fluid in your bloodstream, the higher your blood pressure. In the long run, it can permanently damage your kidneys leading to kidney failure and require dialysis.
  • Allergic Reactions: NSAIDs can also cause extreme allergic reactions, especially in people with asthma. Many specialists recommend that people who have asthma stay away from any NSAID.

Mangosteen and Arthritis - What Is a COX-2 Inhibitor and What Are the Risks of It?

COX-2 Inhibitors are a type of NSAID, were specifically designed to avoid the gastrointestinal problems. Instead of affecting both COX-1 and COX-2 enzymes, COX-2 inhibitor only block the COX-2 enzyme. These drugs don’t affect the prostaglandins that protect the lining of your stomach.

However, there is a downside. COX-1 and COX-2 enzymes are like 2 "business partners" working together to accomplish certain tasks. COX-1 enzymes also help make a chemical that encourages blood clotting and tightens the arteries. These effects are being checked and controlled by another chemical called prostacyclin. But prostacyclin is made, in part, with the help of COX-2 enzymes. Blocking only COX-2 causes imbalance and the effects of blood clotting are unchecked, as a result, it increases the risk of heart attacks and strokes.

This is why COX-2 inhibitors have been linked to an increased risk of heart attacks and strokes. Vioxx and Bextra, both are COX-2 inhibitor, were withdrawn from the market.

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Mangosteen and Arthritis – Why Mangosteen?

Based on research studies, the xanthones, chemical compounds found in mangosteen can suppress acute and chronic inflammation, and selectively inhibit COX-2 enzyme without causing any side effects such as gastrointestinal problems. In another paper studying mangosteen’s effect on inflammation, it was noted that xanthones do not interfere with the clotting mechanisms of blood or produce stomach ulcers.

Based on some personal experience, a good number of patients with chronic arthritis were even able to get off or reduce their prescription medication. The results often can be noted as little as a few days to beyond 90 days.


Mangosteen and Arthritis Precaution:

Mangosteen may not offer the cure, it provides the extra energy needed to combat the disease, assists you in reducing the pain and helps you to deal with some of the side effects caused by the drugs. However, there is one catch here, you need time to find out if the supplement works for you. Also, if you are taking prescribed drugs, check with your doctor on any potential interference with the drugs. 

Based on Dr Templeman's "Mangosteen and Arthritis" booklet, the benefits of taking mangosteen juice can be summarised as below:


  • Anti-Inflammatory: Majority of mangosteen benefits will come from its anti-inflammatory effects because it blocks the COX enzymes that are pro-inflammatory without causing any gastrointestinal side effects. The mangosteen helps to reduce the pain and swelling you feel.
  • Antioxidant: One of the reasons of getting disease is the degenerative of your particular cells. As you age, the ability to repair the damage at cellular level has declined. In arthritis, this means that your ability to repair the process of the cartilage. Antioxidant works on cellular level to remove these free radicals and helps in your healing process.
  • Increase Energy Helps to Combat Arthritis: Appropriate exercise recommended by your physical therapist is highly desirable to improve arthritis. Often, the fear of pain while beginning an exercise program is overwhelming. Mangosteen juice supplement helps support the energy required and for the modulation for pain and anxiety.

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Mangosteen and Arthritis – Recommended Serving Guidelines

1 oz (30ml) 3 times daily until results are seen. Then gradually reduce to the maintenance dose of 1 oz (30ml) daily. For flare-ups such as are experienced in gout and rheumatoid arthritis, a doubling of the servings during the attack is helpful..

The supplement is best to take with food : before/during/immediately within 30 minutes after the meal.

Do not stop any medication, but rather add into current treatment. Monitor your progress daily and see if you feel any improvement. If the mangosteen juice is the only variable in diet and treatment, the mangosteen has a positive result on you!

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Reference

J. Frederic Templeman, M.D., The 90-day Mangosteen Action Plan, Orem, Utah, USA, Sound Concepts, 2005.

J. Frederic Templeman, M.D., Authoritative Answers to Medical Questions, Orem, Utah, USA, Sound Concepts, 2005.

J. Frederic Templeman, M.D., Mangosteen The X-Factor, Orem, Utah, USA, Sound Concepts, 2005.

COX-2 Inhibitor and NSAIDs, webmd (Assessed 1st June 2009)


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